Did people in early modern Europe have a concept of an inner self? Carla Mazzio and Douglas Trevor have brought together an outstanding group of literary, cultural, and history scholars to answer this intriguing question. Through a synthesis of historicism and psychoanalytic criticism, the contributors explore the complicated, nuanced, and often surprising union of history and subjectivity in Europe centuries before psychoanalytic theory. Addressing such topics as "fetishes and Renaissances," "the cartographic unconscious," and "the topographic imaginary," these essays move (...) beyond the strict boundaries of historicism and psychoanalysis to carve out new histories of interiority in early modern Europe. Contributors: Ann Rosalind Jones, Peter Stallybrass, James R. Siemon, John Guillory, Eric Wilson, Karen Newman, Tom Conley, Jeffrey Masten, Carla Mazzio, Katharine Eisaman Maus, Jonathan Goldberg, Douglas Trevor, Kathryn Schwarz, David Hillman, Marjorie Garber. (shrink)

The exhibition Off Beat: Jeff Nuttall and the International Underground showcases the archive of Jeff Nuttall, a painter, poet, editor, actor and novelist. As the exhibition illustrates, Nuttall was a central figure in the International Underground during the 1960s through to the early 1970s. During this time he collaborated with a vast network of avant-garde writers from across the globe, as well as editing the influential publication My Own Mag between 1963 and 1967.

Many are calling for concrete mechanisms of oversight for health research involving artificial intelligence (AI). In response, institutional review boards (IRBs) are being turned to as a familiar model of governance. Here, we examine the IRB model as a form of ethics oversight for health research that uses AI. We consider the model's origins, analyze the challenges IRBs are facing in the contexts of both industry and academia, and offer concrete recommendations for how these committees might be adapted in order (...) to provide an effective mechanism of oversight for health‐related AI research. (shrink)

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

In order to improve our understanding of the components that reflect functionally important processes during reward anticipation and consumption, we used principle components analyses (PCA) to separate and quantify averaged ERP data obtained from each stage of a modified monetary incentive delay (MID) task. Although a small number of recent ERP studies have reported that reward and loss cues potentiate ERPs during anticipation, action preparation, and consummatory stages of reward processing, these findings are inconsistent due to temporal and spatial overlap (...) between the relevant electrophysiological components. Our results show three components following cue presentation are sensitive to incentive cues (N1, P3a, P3b). In contrast to previous research, reward‐related enhancement occurred only in the P3b, with earlier components more sensitive to break‐even and loss cues. During feedback anticipation, we observed a lateralized centroparietal negativity that was sensitive to response hand but not cue type. We also show that use of PCA on ERPs reflecting reward consumption successfully separates the reward positivity from the independently modulated feedback‐P3. Last, we observe for the first time a new reward consumption component: a late negativity distributed over the left frontal pole. This component appears to be sensitive to response hand, especially in the context of monetary gain. These results illustrate that the time course and sensitivities of electrophysiological activity that follows incentive cues do not follow a simple heuristic in which reward incentive cues produce enhanced activity at all stages and substages. (shrink)

Theory in Africa, Africa in Theory explores the place of Africa in archaeological theory, and the place of theory in African archaeology. The centrality of African models in reconstructions is explored, focusing on materiality and agency in the past. The differences between how African models are used in western theoretical discourse and the use of that theory within Africa are also highlighted, as a means to explore the nature of theory itself. Thus, this dual purposed volume is a timely intervention (...) into archaeological theory, deconstructing the taken-for-granted foundations of the ways we approach the past. (shrink)

This paper is a continuation of the authors' work , where the main problem considered was whether a given recursive structure is recursively isomorphic to a polynomial-time structure. In that paper, a recursive Abelian group was constructed which is not recursively isomorphic to any polynomial-time Abelian group. We now show that if every element of a recursive Abelian group has finite order, then the group is recursively isomorphic to a polynomial-time group. Furthermore, if the orders are bounded, then the group (...) is recursively isomorphic to a polynomial-time group with universe A being the set of tally representations of natural numbers Tal = s{;1s};* or the set of binary representations of the natural numbers Bin. We also construct a recursive Abelian group with all elements of finite order but which has elements of arbitrary large finite order which is not isomorphic to any polynomial-time group with universe Tal or Bin. Similar results are obtained for structures , where f is a permutation on the set A. (shrink)

The central problem considered in this paper is whether a given recursive structure is recursively isomorphic to a polynomial-time structure. Positive results are obtained for all relational structures, for all Boolean algebras and for the natural numbers with addition, multiplication and the unary function 2x. Counterexamples are constructed for recursive structures with one unary function and for Abelian groups and also for relational structures when the universe of the structure is fixed. Results are also given which distinguish primitive recursive structures, (...) exponential-time structures and structures with honest witnesses. (shrink)

A Π01 class is an effectively closed set of reals. We study properties of these classes determined by cardinality, measure and category as well as by the complexity of the members of a class P. Given an effective enumeration {Pe:e < ω} of the Π01 classes, the index set I for a certain property is the set of indices e such that Pe has the property. For example, the index set of binary Π01 classes of positive measure is Σ02 complete. (...) Various notions of boundedness are discussed and classified. For example, the index set of the recursively bounded classes is Σ03 complete and the index set of the recursively bounded classes which have infinitely many recursive members is Π04 complete. Consideration of the Cantor-Bendixson derivative leads to index sets in the transfinite levels of the hyperarithmetic hierarchy. (shrink)

We develop a theory of LOGSPACE structures and apply it to construct a number of examples of Abelian Groups which have LOGSPACE presentations. We show that all computable torsion Abelian groups have LOGSPACE presentations and we show that the groups ${\mathbb {Z}, Z(p^{\infty})}$ , and the additive group of the rationals have LOGSPACE presentations over a standard universe such as the tally representation and the binary representation of the natural numbers. We also study the effective categoricity of such groups. For (...) example, we give conditions are given under which two isomorphic LOGSPACE structures will have a linear space isomorphism. (shrink)

The problem of when a recursive graph has a recursive k-coloring has been extensively studied by Bean, Schmerl, Kierstead, Remmel, and others. In this paper, we study the polynomial time analogue of that problem. We develop a number of negative and positive results about colorings of polynomial time graphs. For example, we show that for any recursive graph G and for any k, there is a polynomial time graph G′ whose vertex set is {0,1}* such that there is an effective (...) degree preserving correspondence between the set of k-colorings of G and the set of k-colorings of G′ and hence there are many examples of k-colorable polynomial time graphs with no recursive k-colorings. Moreover, even though every connected 2-colorable recursive graph is recursively 2-colorable, there are connected 2-colorable polynomial time graphs which have no primitive recursive 2-coloring. We also give some sufficient conditions which will guarantee that a polynomial time graph has a polynomial time or exponential time coloring. (shrink)

We examine the effective categoricity of equivalence structures via Ershov's difference hierarchy. We explore various kinds of categoricity available by distinguishing three different notions of isomorphism available in this hierarchy. We prove several results relating our notions of categoricity to computable equivalence relations: for example, we show that, for such relations, computable categoricity is equivalent to our notion of weak ω-c.e. categoricity, and that $\Delta _2^0 $ -categoricity is equivalent to our notion of graph-ω-c.e. categoricity.

This essay is the journal editor's introduction to part 3 of an ongoing symposium on quietism. With reference to writings of James Joyce, Francis Picabia, J. M. Coetzee, Charles Taylor, Alasdair MacIntyre, Elaine Pagels, and Karen King—and with extended reference to Jonathan Lear's study of “cultural devastation,” Radical Hope—Jeffrey Perl explores the possibility that the fear of anomie is misplaced. He argues that, in comparison with the violence and narrowness of any given social order, anomie may well be preferable, (...) and, in any case, may be no more than another name for quietism. (shrink)

This essay is the journal editor's introduction to part 3 of an ongoing symposium on quietism. With reference to writings of James Joyce, Francis Picabia, J. M. Coetzee, Charles Taylor, Alasdair MacIntyre, Elaine Pagels, and Karen King—and with extended reference to Jonathan Lear's study of “cultural devastation,” Radical Hope—Jeffrey Perl explores the possibility that the fear of anomie (“anomiphobia”) is misplaced. He argues that, in comparison with the violence and narrowness of any given social order, anomie may well be (...) preferable, and, in any case, may be no more than another name for quietism. (shrink)

We study computability theoretic properties of and equivalence structures and how they differ from computable equivalence structures or equivalence structures that belong to the Ershov difference hierarchy. Our investigation includes the complexity of isomorphisms between equivalence structures and between equivalence structures.

A computable graph is constructed which is not computably isomorphic to any polynomial-time graph with a standard universe . Conditions are given under which a computable graph is computably isomorphic to a polynomial-time graph with a standard universe — for example, if every vertex has finite degree. Two special types of graphs are studied. It is shown that any computable tree is recursively isomorphic to a p-time tree with standard universe and that any computable equivalence relation is computably isomorphic to (...) a p-time equivalence relation with standard universe. (shrink)

Index sets are used to measure the complexity of properties associated with the differentiability of real functions and the existence of solutions to certain classic differential equations. The new notion of a locally computable real function is introduced and provides several examples of Σ04 complete sets.

This essay introduces a Common Knowledge symposium on the relationship between texts (for instance, musical scores or dramatic scripts) and performance in the arts by drawing out its implications for the interpretation of publicly consequential texts (such as constitutions, legal statutes, and canon law). Arguing that judges and clerics could learn much from studying the work of Philip Gossett and other practitioners of textual criticism in the arts, the essay suggests that a wider array of choices exists for legal interpretation (...) than the usual alternative between originalism or literalism, on the one hand, and intuitionism, on the other hand. Contributions to the symposium (titled “Between Text and Performance”) emphasize what Roger Moseley calls “improvisatory fluency in historical idioms,” and this introduction recommends that jurists develop for the law the kind of “ear” that musicians must have when a score invites or demands improvisation. (shrink)

In this article, we discuss a hypothesis to explain the preferential synthesis of the superoxide sensitive form of aconitase in mitochondria and the phenotype observed in manganese superoxide dismutase mutant mice, which show a gross over accumulation of stored fat in liver. The model proposes that intermediary metabolism is redox regulated by mitochondrial superoxide generated during mitochondrial respiration. This regulates the level of reducing equivalents (NADH) entering the electron transport chain (ETC) through the reversible inactivation of mitochondrial aconitase. This control (...) mechanism has a dual function; firstly, it regulates levels of superoxide generated by the ETC and, secondly, it fine‐tunes metabolism by channeling citrate either for the production of NADH for energy metabolism or diverting it for the synthesis of fats. In this setting, the mitochondrial redox state influences metabolic decisions via a superoxide–aconitase rheostat. BioEssays 26:894–900, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

An ω-language is a set of infinite sequences on a countable language, and corresponds to a set of real numbers in a natural way. Languages may be described by logical formulas in the arithmetical hierarchy and also may be described as the set of words accepted by some type of automata or Turing machine. Certain families of languages, such as the equation image languages, may enumerated as P0, P1, … and then an index set associated to a given property R (...) of languages is just the set of e such that Pe has the property. The complexity of index sets for 7 types of languages is determined for various properties related to the size of the language. (shrink)

We give resource bounded versions of the Completeness Theorem for propositional and predicate logic. For example, it is well known that every computable consistent propositional theory has a computable complete consistent extension. We show that, when length is measured relative to the binary representation of natural numbers and formulas, every polynomial time decidable propositional theory has an exponential time (EXPTIME) complete consistent extension whereas there is a nondeterministic polynomial time (NP) decidable theory which has no polynomial time complete consistent extension (...) when length is measured relative to the binary representation of natural numbers and formulas. It is well known that a propositional theory is axiomatizable (respectively decidable) if and only if it may be represented as the set of infinite paths through a computable tree (respectively a computable tree with no dead ends). We show that any polynomial time decidable theory may be represented as the set of paths through a polynomial time decidable tree. On the other hand, the statement that every polynomial time decidable, relative to the tally representation of natural numbers and formulas, is equivalent to P = NP. For predicate logic, we develop a complexity theoretic version of the Henkin construction to prove a complexity theoretic version of the Completeness Theorem. Our results imply that that any polynomial space decidable theory △ possesses a polynomial space computable model which is exponential space decidable and thus △ has an exponential space complete consistent extension. Similar results are obtained for other notions of complexity. (shrink)

Academic integrity violations on college campuses continue to be a significant concern that draws public attention. Even though AI has been the subject of numerous studies offering explanations and recommendations, academic dishonesty persists. Consequently, this has rekindled interest in understanding AI behavior and its influencers. This paper focuses on the AI violations of plagiarism and sharing homework for freshman business students, examining the factors that influence a student’s intention to plagiarize or share homework with others. Using a sample of more (...) than 1300 freshman business students over 2 years, we modeled intent to plagiarize and intent to share homework using factors in the Theory of Planned Behavior in addition to past violation behavior and moral obligation. Based on the results of this study, attitude, perceived behavioral control, subjective norm, and in addition past behavior and moral obligation, were found to significantly influence an individual’s intention to violate academic integrity, explaining 33 and 35 % of the variance in intention to commit an AI violation for sharing homework and plagiarism, respectively. These results contribute to a better understanding of individuals’ motivations for plagiarizing and sharing homework, which is a necessary step toward reducing academic integrity violations. (shrink)

Epidemiology is a core science of public health, focusing on research related to the distribution and determinants of both positive and adverse health states and events and on application of knowledge gained to improve public health. The American College of Epidemiology (ACE) is a professional organization devoted to the professional practice of epidemiology. As part of that commitment, and in response to concerns for more explicit attention to core values and duties of epidemiologists in light of emerging issues and increased (...) scrutiny of epidemiology, the College developed, adopted, and published a set of Ethics Guidelines. The structure of the ACE ethics guidelines is in four parts: (1) a brief statement of core values and duties of epidemiologists, coupled with the virtues important to professional practice; (2) concise statements of key duties and obligations; (3) exposition of the duties and obligations with more applications; and (4) a brief summary and conclusion. The Guidelines have been published on the ACE website and in the official College journal Annals of Epidemiology. The guidelines contain (and maintain) core elements that define the discipline of epidemiology and its fundamental duties, but they are also intended to be dynamic and evolving, responsive to a changing professional and social environment. (shrink)

All of inquiry is a mental process from the known to the unknown within the realm of possibility. This process uses the three faculties of perception, conception, and abstraction, all fueled by information. These faculties have corollaries in Science and Philosophy of Religion. It is the thesis of this book that if these faculties are intelligible and reliability in Science, there is no reason to reject them when used in other fields of inquiry.

Umberto Eco’s notion of an “open work” embraces a Peircean pragmatism in order to avoid the extremes of both a bounded authorial intent and an unbounded post-structuralism, but this brand of pragmatism does not succeed in providing objective constraints on interpretation due to an unnecessary commitment to a Saussurrean net of meaning signification. Eco’s arguments for this commitment fail upon simple phenomenological reflection, and the whole commitment proves to be unnecessary for Eco’s fruitful insights of the open work. Successful interpretation (...) of an open work requires both intersubjectivity and actual presence. (shrink)

How do we go about understanding the "classic texts" of sociological theory? This paper begins by reviewing the historicist position of Jones, with its foundations in the work of Quentin Skinner and other historians of political theory. This position then is criticized from the standpoint of the neo-Deweyan pragmatism of Richard Rorty. Specifically, Rorty's pragmatism encourages us to revise Skinner's and Jones's historicism on three specific points: the acceptance of treatments of classical texts that are undeniably anachronistic but (...) nonetheless unobjectionable; the restriction of Skinner's notion of an agent's "privileged access" to his or her intentions; and the adoption of a view of the history of sociological theory as a succession of vocabularies-a view that encourages a new kind of dialogue between historians of sociological theory and theorists themselves. The last point is articulated in a concrete example of the interpretation of one of Durkheim's most characteristic arguments. The conclusion again stresses the benefits to be derived from viewing sociological theory-both past and present-from this pragmatist perspective. (shrink)

The four coauthors describe the twenty-five-year history of efforts of the Council of Learned Societies in Education (CLSE) to represent the interests of the social foundations of education in the National Council for Accreditation of Teacher Education (NCATE), including the evolution of CLSE into the Council for the Social Foundations of Education and its recent departure from NCATE after a quarter century of successful involvement. The coauthors, each personally supportive of foundational involvement in national accreditation, delineate advantages gained by both (...) CLSE and NCATE during the quarter century of involvement, while also describing concerns and arguments that have led to the current disassociation of the Council for Social Foundations of Education (CSFE) fromNCATE. The article concludes with suggestions for the future and the coauthors' hope that this history and chronicle will provide incentive for reinvolvement of the foundations in national accreditation circles. (shrink)

Guided by photographer Jeff Jones's sure and well-developed vision, Arctic Sanctuary leads the reader on a remarkable journey that few of us will ever take in real life: a trek deep into Alaska's Arctic National Wildlife Refuge. By turns celebratory and contemplative, emotionally evocative and beautifully fierce, this collection of lyrical essays and stunning panoramic photographs pays homage to a vast and remote land that remains untamed by technology and undisturbed by human development. A rare window into a world (...) that is whole, ecologically intact, and still driven by ancient evolutionary energies, Arctic Sanctuary invites us to examine our own ideas of the wilderness ethic in the modern world. (shrink)

While the bioethics literature demonstrates that the field has spent substantial time and thought over the last four decades on the goals, methods, and desired outcomes for service and training in bioethics, there has been less progress defining the nature and goals of bioethics research and scholarship. This gap makes it difficult both to describe the breadth and depth of these areas of bioethics and, importantly, to gauge their success. However, the gap also presents us with an opportunity to define (...) this scope of work for ourselves and to help shape the broader conversation about the impact of academic research. Because of growing constraints on academic funding, researchers and scholars in many fields are being asked to demonstrate and also forecast the value and impact of their work. To do that, and also to satisfy ourselves that our work has meaningful effect, we must understand how our work can motivate change and how that change can be meaningfully measured. In a field as diverse as bioethics, the pathways to and metrics of change will likewise be diverse. It is therefore critical that any assessment of the impact of bioethics research and scholarship be informed by an understanding of the nature of the work, its goals, and how those goals can and ought to be furthered. In this paper, we propose a conceptual model that connects individual bioethics projects to the broader goals of scholarship, describing the translation of research and scholarly output into changes in thinking, practice, and policy. One of the key implications of the model is that impact in bioethics is generally the result of a collection of projects rather than of any single piece of research or scholarship. Our goal is to lay the groundwork for a thoroughgoing conversation about bioethics research and scholarship that will advance and shape the important conversation about their impact. (shrink)

Distributional models of semantics learn word meanings from contextual co‐occurrence patterns across a large sample of natural language. Early models, such as LSA and HAL (Landauer & Dumais, 1997; Lund & Burgess, 1996), counted co‐occurrence events; later models, such as BEAGLE (Jones & Mewhort, 2007), replaced counting co‐occurrences with vector accumulation. All of these models learned from positive information only: Words that occur together within a context become related to each other. A recent class of distributional models, referred to (...) as neural embedding models, are based on a prediction process embedded in the functioning of a neural network: Such models predict words that should surround a target word in a given context (e.g., word2vec; Mikolov, Sutskever, Chen, Corrado, & Dean, 2013). An error signal derived from the prediction is used to update each word's representation via backpropagation. However, another key difference in predictive models is their use of negative information in addition to positive information to develop a semantic representation. The models use negative examples to predict words that should not surround a word in a given context. As before, an error signal derived from the prediction prompts an update of the word's representation, a procedure referred to as negative sampling. Standard uses of word2vec recommend a greater or equal ratio of negative to positive sampling. The use of negative information in developing a representation of semantic information is often thought to be intimately associated with word2vec's prediction process. We assess the role of negative information in developing a semantic representation and show that its power does not reflect the use of a prediction mechanism. Finally, we show how negative information can be efficiently integrated into classic count‐based semantic models using parameter‐free analytical transformations. (shrink)

This study examines the conflation of terms such as “knowledge” and “understanding” in peer-reviewed literature, and tests the hypothesis that little current research clearly distinguishes between importantly distinct epistemic states. Two sets of data are presented from papers published in the journal Public Understanding of Science. In the first set, the digital text analysis tool, Voyant, is used to analyze all papers published in 2014 for the use of epistemic success terms. In the second set of data, all papers published (...) in Public Understanding of Science from 2010–2015 are systematically analyzed to identify instances in which epistemic states are empirically measured. The results indicate that epistemic success terms are inconsistently defined, and that measurement of understanding, in particular, is rarely achieved in public understanding of science studies. We suggest that more diligent attention to measuring understanding, as opposed to mere knowledge, will increase efficacy of scientific outreach and communication efforts. (shrink)

Western philosophy’s relationship with prisons stretches from Plato’s own incarceration to the modern era of mass incarceration. Philosophy Imprisoned: The Love of Wisdom in the Age of Mass Incarceration draws together a broad range of philosophical thinkers, from both inside and outside prison walls, in the United States and beyond, who draw on a variety of critical perspectives (including phenomenology, deconstruction, and feminist theory) and historical and contemporary figures in philosophy (including Kant, Hegel, Foucault, and Angela Davis) to think about (...) prisons in this new historical era. All of these contributors have experiences within prison walls: some are or have been incarcerated, some have taught or are teaching in prisons, and all have been students of both philosophy and the carceral system. The powerful testimonials and theoretical arguments are appropriate reading not only for philosophers and prison theorists generally, but also for prison reformers and abolitionists. (shrink)

We investigate notions of randomness in the space ${{\mathcal C}(2^{\mathbb N})}$ of continuous functions on ${2^{\mathbb N}}$ . A probability measure is given and a version of the Martin-Löf test for randomness is defined. Random ${\Delta^0_2}$ continuous functions exist, but no computable function can be random and no random function can map a computable real to a computable real. The image of a random continuous function is always a perfect set and hence uncountable. For any ${y \in 2^{\mathbb N}}$ , (...) there exists a random continuous function F with y in the image of F. Thus the image of a random continuous function need not be a random closed set. The set of zeroes of a random continuous function is always a random closed set. (shrink)

Experts identified water quality, manure, good handling practices (including personal hygiene and equipment sanitation), and traceability as critical farm problem areas that, if addressed, are likely to decrease risk associated with microbial contamination of fresh produce from all scales of agriculture. However, the diverse nature of production strategies used by produce farmers presents multiple options for addressing foodborne illness issues while simultaneously creating potential complications. We use a mental models methodology to enhance our understanding of the underlying factors and assumptions (...) of small, medium, and large produce growers that influence their decision-making processes for contamination prevention and control. This empirical evidence demonstrates how challenges and opportunities to food safety are related to the scale of production and marketing strategies. We believe that refining the development of standards and existing extension and outreach food safety programs are important to both consumer protection and supporting agricultural communities. Additionally, this approach will help develop and refine food safety programs that will result in empirically grounded recommendations based on identified grower information needs. (shrink)